CAENORHABDITIS ELEGANS EXPRESSING THE SACCHAROMYCES CEREVISIAE NADH ALTERNATIVE DEHYDROGENASE NDI1P, AS A TOOL TO IDENTIFY NEW GENES INVOLVED IN COMPLEX I RELATED DISEASES

Isolated complex I deficiencies are one of the most commonly observed biochemical features in patients suffering from mitochondrial disorders.In the majority of these clinical cases the molecular bases of the diseases remain unknown suggesting the involvement of unidentified factors that are critical for complex I function.The Saccharomyces cerevis

An oronasal fistula (ONF) is an abnormal structure between the oral and nasal cavities, which is a common complication of cleft palate repair due to the failure of wound healing.When some patients with ONF are unsuitable for secondary surgical repair, the obturator treatment becomes a potential method.The objectives of the obturator treatment shoul

Background: Surgical scars cause an intra-atrial conduction delay and anatomical obstacles that facilitate the perpetuation of atrial flutter (AFL).This study aimed to investigate the nightstick twm-850xl outcome and predictor of recurrent atrial tachyarrhythmia after catheter ablation in patients with prior cardiac surgery for valvular heart disea

ABSTRACTCells activate protective mechanisms to overcome stressful conditions that threaten cellular homeostasis, including imbalances in calcium, redox, and nutrient levels.Endoplasmic reticulum (ER) stress activates an intracellular signaling pathway, known as the unfolded protein response (UPR), to mitigate such circumstances and protect cells.A